Powerful and Real-Time Quantification of Antifungal Efficacy against Triazole-Resistant and -Susceptible Aspergillus fumigatus Infections in Galleria mellonella by Longitudinal Bioluminescence Imaging
Eliane Vanhoffelen, Lauren Michiels, Matthias Brock, Katrien Lagrou, Agustin Reséndiz-Sharpe, Greetje Vande Velde
Abstract
Triazole-resistant Aspergillus fumigatus strains are rapidly emerging, and resistant infections are difficult to treat, causing mortality rates of up to 88%. The recent WHO priority list underscores A. fumigatus as one of the most critical fungal pathogens for which innovative antifungal treatment should be (urgently) prioritized.
Topics & Concepts
Galleria mellonellaAspergillus fumigatusMicrobiologyIn vivoBioluminescence imagingBiologyAspergillosisVirulenceImmunologyLuciferaseBiotechnologyTransfectionGeneticsCell cultureGeneBiochemistryAntifungal resistance and susceptibilityAntimicrobial Peptides and ActivitiesEntomopathogenic Microorganisms in Pest Control