In Vitro and In Vivo Wound Healing and Anti‐Inflammatory Activities of Babassu Oil (<i>Attalea speciosa</i> Mart. Ex Spreng., Arecaceae)
José Alex Alves dos Santos, José Wellinton da Silva, Simone M. Santos, Maria de Fátima Rodrigues, Camila Joyce Alves da Silva, Márcia Vanusa da Silva, Maria Tereza dos Santos Correia, Julianna Ferreira Cavalcanti de Albuquerque, Cristiane Moutinho Lagos de Melo, Teresinha Gonçalves da Silva, René Duarte Martins, Francisco Carlos A. Aguiar Júnior, Rafael Matos Ximenes
Abstract
Babassu ( Attalea speciosa Mart. ex Spreng., Arecaceae) is a palm tree endemic to Brazil and found mainly in the borders of Amazon forest, where the harvesting of its fruits is an important source of income for more than 300,000 people. Among the communities of coconut breakers women, babassu oil is used in culinary, as fuel, and mostly as medicinal oil for the treatment of skin wounds and inflammation. This study aimed to evaluate in vitro and in vivo the wound healing effects of babassu oil. In vitro, babassu oil increased the migration of L929 fibroblasts, inhibited the production of nitric oxide by LPS‐stimulated peritoneal macrophages, and increased the levels of INF‐ γ and IL‐6 cytokines production. In vivo, babassu oil accelerated the healing process in a full‐thickness splinted wound model, by an increase in the fibroblasts number, blood vessels, and collagen deposition in the wounds. The babassu oil also increased the recruitment of inflammatory cells into the wound site and showed an anti‐inflammatory effect in a chronic ear edema model, reducing ear thickness, epidermal hyperplasia, and myeloperoxidase activity. Thus, these data corroborate the use of babassu oil in folk medicine as a remedy to treat skin wounds.