Microsatellite Status Detection of Colorectal Cancer: Evaluation of Inconsistency between PCR and IHC
Jielin Chen, Qijia Yan, Jingyue Sun, Qingyi Wang, Yongguang Tao, Desheng Xiao, Bin Xie
Abstract
Our study demonstrated a high concordance between the PCR and IHC results. In order to reduce the ineffective treatment of ICIs due to MSI misdiagnosis, the patient's age, gender, tumor location and degree of differentiation should be included in the clinician's selection of MSI testing in colorectal cancer.
Topics & Concepts
Microsatellite instabilityMLH1MSH6MSH2Colorectal cancerPMS2MicrosatelliteMedicineInternal medicineDNA mismatch repairImmunohistochemistryOncologyCancerLynch syndromeBiologyGeneticsGeneAlleleGenetic factors in colorectal cancerColorectal Cancer Treatments and StudiesCancer Immunotherapy and Biomarkers