The role of long non-coding RNA H19 in infertility
Yuanyuan Peng, Ren-Hao Guo, Bei Shi, Da Li
Abstract
Infertility is defined as the failure to conceive after at least one year of unprotected intercourse. Long non-coding RNAs (lncRNAs) are transcripts that contain more than 200 nucleotides but do not convert into proteins. LncRNAs, particularly lncRNA H19, have been linked to the emergence and progression of various diseases. This review focuses on the role of H19 in infertility caused by polycystic ovary syndrome, endometriosis, uterine fibroids, diminished ovarian reserve, male factor, and assisted reproductive technology-related pathology, highlighting the potential of H19 as a molecular target for the future treatment of infertility.
Topics & Concepts
InfertilityPolycystic ovaryEndometriosisFemale infertilityGynecologyBiologyMedicinePregnancyEndocrinologyGeneticsInsulinInsulin resistanceEndometriosis Research and TreatmentReproductive System and PregnancyEndometrial and Cervical Cancer Treatments