Tumor acidity-responsive polymeric nanoparticles to promote intracellular delivery of zoledronic acid by PEG detachment and positive charge exposure for enhanced antitumor potency
Ya-Hsuan Chou, Yuling Liu, Tsai‐Ching Hsu, Jia-Le Yow, Bor‐Show Tzang, Wen‐Hsuan Chiang
Abstract
and inhibited tumor growth, thereby increasing the survival rate of the treated mice. The collective data suggest the great promise of tumor acidity-sensitive ZA-carrying hybrid nanoparticles in the treatment of extraskeletal solid tumors.
Topics & Concepts
Ethylene glycolChemistryPolyethylene glycolPEG ratioZoledronic acidNanoparticleNuclear chemistryMaterials scienceBiophysicsOrganic chemistryNanotechnologyMedicineFinanceEconomicsBiologySurgeryNanoparticle-Based Drug DeliveryBone health and treatmentsNanoplatforms for cancer theranostics