Gramine-based structure optimization to enhance anti-gastric cancer activity
Xinhui Zhang, Qian Guo, Heng-Ying Wang, Yihan Li, Mussa Yussuf Khamis, Liying Ma, Bo Wang, Hong‐Min Liu
Topics & Concepts
PharmacophoreChemistryCancerCancer cellIndole testApoptosisCell cycle checkpointStructure–activity relationshipIC50Cancer researchBiochemistryCell cyclePharmacologyStereochemistryIn vitroInternal medicineBiologyMedicineSynthesis and bioactivity of alkaloidsSynthesis and Biological EvaluationCancer therapeutics and mechanisms