A Review on the Role of miR-149-5p in the Carcinogenesis
Soudeh Ghafouri‐Fard, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Sepideh Kadkhoda, Mohammad Taheri, Arash Tafrishinejad
Abstract
gene on 2q37.3. The miR-149 hairpin produces miR-149-5p and miR-149-3p, which are the "guide" and the sister "passenger" strands, respectively. Deep sequencing experiments have shown higher prevalence of miR-149-5p compared with miR-149-3p. Notably, both oncogenic and tumor suppressive roles have been reported for miR-149-5p. In this review, we summarize the impact of miR-149-5p in the tumorigenesis and elaborate mechanisms of its involvement in this process in a variety of neoplastic conditions based on three lines of evidence, i.e., in vitro, in vivo and clinical settings.
Topics & Concepts
CarcinogenesisComputational biologyBiologyCancer researchGeneticsCancerMicroRNA in disease regulationCircular RNAs in diseasesCancer-related molecular mechanisms research