Palladium-Catalyzed C–H Allylation of Electron-Deficient Polyfluoroarenes with gem-Difluorinated Cyclopropanes
Ping‐Xin Zhou, Xiaozhe Yang, Jia Wang, Chunpo Ge, Feng Wang, Yong‐Min Liang, Yu Zhang
Abstract
A palladium-catalyzed C-H allylation of electron-deficient polyfluoroarenes with gem-difluorinated cyclopropanes is reported. It provides a useful and facile approach to 2-fluoroallylic polyfluoroarenes in moderate to excellent yields with high Z-selectivity. In addition, this new approach has good functional group compatibility and broad substrate scope.
Topics & Concepts
ChemistryPalladiumCatalysisMedicinal chemistryCyclopropaneCombinatorial chemistryOrganic chemistryRing (chemistry)Fluorine in Organic ChemistryCyclopropane Reaction MechanismsCatalytic C–H Functionalization Methods