Severe impairment of T-cell responses to BNT162b2 immunization in patients with multiple myeloma
Julius C. Enßle, Julia Campe, Amelie Schwenger, Eliza Wiercinska, Helen Hellstern, Ralf Dürrwald, Michael A. Rieger, Sebastian Wolf, Olivier Balló, Björn Steffen, Hubert Serve, Halvard Bönig, Holger F. Rabenau, Marek Widera, Sandra Ciesek, Ivana von Metzler, Evelyn Ullrich
Abstract
Three reports address the protection of the vulnerable population of patients with hematologic malignancies in the face of the ongoing COVID pandemic. The reports suggest that some patients who fail to mount a B-cell response to vaccine may nevertheless have protective T cell responses. As a group, these reports suggest that patients should continue to be immunized with additional doses to attempt to improve immune response but that they need to maintain the precautions recommended for the unvaccinated.