A thermo-responsive hydrogel loaded with an ionic liquid microemulsion for transdermal delivery of methotrexate
Yang Shu, Rong Xue, Yiru Gao, Wenxin Zhang, Jianhua Wang
Abstract
A thermally responsive hydrogel loading ionic liquid microemulsion (IL-ME) facilitates transdermal delivery of methotrexate (MTX). The loading of the MTX-containing IL-ME on the Gel led to a significant increase in MTX permeation.
Topics & Concepts
TransdermalMicroemulsionMethotrexateMaterials scienceIonic liquidChemical engineeringChromatographyPharmacologyOrganic chemistryChemistrySurgeryMedicinePulmonary surfactantEngineeringCatalysisAdvanced Drug Delivery SystemsAdvancements in Transdermal Drug DeliverySurfactants and Colloidal Systems