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Increased Small Ubiquitin-like Modifier-Activating Enzyme SAE1 Promotes Hepatocellular Carcinoma by Enhancing mTOR SUMOylation

Yuwei Chen, Wei Peng, Qing Tao, Shengfu Li, Zhenru Wu, Yongjie Zhou, Qing Xu, Yuke Shu, Yahong Xu, Mingyang Shao, Menglin Chen, Yujun Shi

2023Laboratory Investigation19 citationsDOIOpen Access PDF

Topics & Concepts

SUMO proteinGene knockdownHepatocellular carcinomaUbiquitinCancer researchBiologyPI3K/AKT/mTOR pathwayEnzymeIn vivoGeneSignal transductionCell biologyBiochemistryGeneticsUbiquitin and proteasome pathways14-3-3 protein interactionsCancer-related Molecular Pathways
Increased Small Ubiquitin-like Modifier-Activating Enzyme SAE1 Promotes Hepatocellular Carcinoma by Enhancing mTOR SUMOylation | Litcius