Metal-Free Late-Stage Alkylation of Tryptophan and Tryptophan-Containing Peptides with 1,3-Dithiane Derivatives
Mingming Mao, Jia Li, Kang Dong, Ruipeng Li, Xi Chen, Jian Liu, Shouchu Tang
Abstract
Late-stage diversification of structurally complex peptides has enormous potential for drug discovery and molecular imaging. We report a simple, metal-free, late-stage reductive C2 alkylation of tryptophan and tryptophan-containing peptides using readily available 1,3-dithianes. This alkylation protocol has a wide substrate scope and an excellent tolerance for reactive functional groups.
Topics & Concepts
ChemistryTryptophanAlkylationCombinatorial chemistryDithianeStereochemistryOrganic chemistryBiochemistryAmino acidCatalysisChemical Synthesis and AnalysisCatalytic C–H Functionalization MethodsSynthesis and Catalytic Reactions