A direct synthesis method towards spirocyclic indazole derivatives <i>via</i> Rh(<scp>iii</scp>)-catalyzed C–H activation and spiroannulation
Jian Zhou, Chuanliu Yin, Tianshuo Zhong, Xiangyun Zheng, Xiao Yi, Junyu Chen, Chuanming Yu
Abstract
A rhodium( iii )-catalyzed [4 + 1] spiroannulation of N -aryl phthalazine-diones (pyridazine-diones) with diazo compounds to construct spirocyclic indazole derivatives with diverse structures is described.
Topics & Concepts
IndazoleChemistryPhthalazinePyridazineRhodiumCatalysisArylDiazoCombinatorial chemistryHydrazine (antidepressant)Medicinal chemistryStereochemistryOrganic chemistryChromatographyAlkylCatalytic C–H Functionalization MethodsCyclopropane Reaction MechanismsSynthesis and Catalytic Reactions