Polyclonal Spread of Fosfomycin Resistance among Carbapenemase-Producing Members of the <i>Enterobacterales</i> in the Czech Republic
Vittoria Mattioni Marchetti, Lucie Kraftova, Marc Finianos, Tsolaire Sourenian, Jaroslav Hrabák, Ibrahim Bitar
Abstract
(CRE) in the Czech Republic. Our study summarizes the main achievements of our research on the use of molecular technologies, such as next-generation sequencing (NGS), to describe the heterogeneous mechanisms that reduce fosfomycin effectiveness in CRE. The results suggest that a program for widespread monitoring of fosfomycin resistance and epidemiology fosfomycin-resistant organisms can aide timely implementation of countermeasures to maintain the effectiveness of fosfomycin.
Topics & Concepts
FosfomycinAntibiotic resistanceAntibioticsMicrobiologyMultiple drug resistanceAntimicrobialCzechBiologyMedicineLinguisticsPhilosophyAntibiotic Resistance in BacteriaUrinary Tract Infections ManagementNephrotoxicity and Medicinal Plants