Lipopolysaccharides transport during fat absorption in rodent small intestine
Yasutada Akiba, Koji Maruta, Takeshi Takajo, Kazuyuki Narimatsu, Hyder Said, Ikuo Kato, Atsukazu Kuwahara, Jonathan D. Kaunitz
2020American Journal of Physiology-Gastrointestinal and Liver Physiology61 citationsDOIOpen Access PDF
Abstract
We report direct in vivo confirmation of transcellular lipopolysaccharides (LPS) uptake from the intestine into the portal vein (PV) involving CD36 and lipid rafts, with minor uptake via the canonical chylomicron pathway. The gut hormone glucagon-like peptide-2 (GLP-2) inhibited uptake into the PV. These data suggest that the bulk of LPS absorption is via the PV to the liver, helping clarify the mechanism of LPS transport into the PV as part of the "gut-liver" axis. These data do not support the paracellular transport of LPS, which has been implicated in the pathogenesis of the "leaky gut" syndrome.
Topics & Concepts
Paracellular transportTranscellularChylomicronSmall intestineIn vivoCD36ChemistryAbsorption (acoustics)Internal medicineEndocrinologyBiologyCell biologyBiochemistryMedicineCholesterolLipoproteinMembraneVery low-density lipoproteinMaterials sciencePermeability (electromagnetism)BiotechnologyComposite materialReceptorClinical Nutrition and GastroenterologyPediatric Hepatobiliary Diseases and TreatmentsGastroesophageal reflux and treatments