SLC14A1 prevents oncometabolite accumulation and recruits HDAC1 to transrepress oncometabolite genes in urothelial carcinoma
Ti‐Chun Chan, Wen‐Jeng Wu, Wei‐Ming Li, Meng‐Shin Shiao, Yow‐Ling Shiue, Chien‐Feng Li
Abstract
gene is a novel tumor suppressor in UCs. Total and membranous SLC14A1 prevents urea and arginine accumulation via the mTOR signaling pathway. Nuclear SLC14A1 recruits HDAC1 to transrepress oncometabolite genes.
Topics & Concepts
Cancer researchCarcinogenesisBiologyGene knockdownEpigeneticsCancerCell cultureGeneGeneticsEpigenetics and DNA MethylationCancer, Hypoxia, and MetabolismCancer-related gene regulation