Rebalancing TGFβ1/BMP signals in exhausted T cells unlocks responsiveness to immune checkpoint blockade therapy
Abbey A. Saadey, Amir Yousif, Nicole Osborne, Roya Shahinfar, Yulin Chen, Brooke Laster, Meera Rajeev, Parker Bauman, Amy Webb, Hazem E. Ghoneim
Topics & Concepts
Immune checkpointCytotoxic T cellBlockadeImmune systemCancer researchImmunologyImmunotherapyCancer immunotherapyCD8EpigeneticsBiologyCell biologyReceptorIn vitroGeneBiochemistryCancer Immunotherapy and BiomarkersCAR-T cell therapy researchImmune cells in cancer