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Design and synthesis of novel quinazolinone-pyrazole derivatives as potential α-glucosidase inhibitors: Structure-activity relationship, molecular modeling and kinetic study

Fateme Azimi, Homa Azizian, Mohammad Najafi, Farshid Hassanzadeh, Hojjat Sadeghi‐Aliabadi, Jahan B. Ghasemi, Mohammad Ali Faramarzi, Somayeh Mojtabavi, Bagher Larijani, Lotfollah Saghaei, Mohammad Mahdavi

2021Bioorganic Chemistry61 citationsDOI

Topics & Concepts

QuinazolinoneChemistryPyrazoleAcarboseStereochemistryMoietyDocking (animal)Active siteEnzymeMolecular modelStructure–activity relationshipIC50In vitroCombinatorial chemistryBiochemistryMedicineNursingQuinazolinone synthesis and applicationsSynthesis and Characterization of Heterocyclic CompoundsSynthesis and biological activity
Design and synthesis of novel quinazolinone-pyrazole derivatives as potential α-glucosidase inhibitors: Structure-activity relationship, molecular modeling and kinetic study | Litcius