Enabling Suzuki–Miyaura coupling of Lewis-basic arylboronic esters with a nonprecious metal catalyst
Michael C. Haibach, Andrew R. Ickes, Sergei Tcyrulnikov, Shashank Shekhar, Sébastien Monfette, Rafal Swiatowiec, Brian Kotecki, Jason Wang, Amanda L. Wall, Rodger F. Henry, Eric C. Hansen
Abstract
Me from Ni(ii) intermediates by Lewis basic reactants and products is disfavored relative to more commonly employed ligands in the Ni-SMC, which allows it to operate efficiently in the presence of Lewis bases such as unhindered pyridines.
Topics & Concepts
ChemistryReactivity (psychology)CatalysisNucleophileLewis acids and basesCombinatorial chemistryHalideCoupling reactionOrganic chemistryElectrophileMedicineAlternative medicinePathologyCatalytic Cross-Coupling ReactionsOrganoboron and organosilicon chemistryCatalytic C–H Functionalization Methods