Inhibition and eradication of <i>Pseudomonas aeruginosa</i> biofilms by secondary metabolites of <i>Nocardiopsis lucentensis</i> EMB25
Nikky Goel, Moumita Ghosh, Deepti Jain, Rajeshwari Sinha, Sunil Kumar Khare
Abstract
confirmed that the secondary metabolites act on two main regulators of the quorum sensing pathway, LasR, and RhlR. The findings of this study support the bioprospecting of previously unknown and extreme-condition actinobacteria as a rich source of novel bioactives against infections caused by bacterial biofilms.
Topics & Concepts
BiofilmPseudomonas aeruginosaMicrobiologyActinobacteriaChemistryBiologyBacteriaBiochemistryGenetics16S ribosomal RNAGeneBacterial biofilms and quorum sensingActinomycetales infections and treatmentAntibiotic Resistance in Bacteria