Expression Regulation and Function of T-Bet in NK Cells
Chen Huang, Jiacheng Bi
Abstract
Natural killer (NK) cells are cytotoxic innate lymphocytes that play an important role in immune surveillance. The development, maturation and effector functions of NK cells are orchestrated by the T-box transcription factor T-bet, whose expression is induced by cytokines such as IFN-γ, IL-12, IL-15 and IL-21 through the respective cytokine receptors and downstream JAK/STATs or PI3K-AKT-mTORC1 signaling pathways. In this review, we aim to discuss the expression and regulation of T-bet in NK cells, the role of T-bet in mouse NK cell development, maturation, and function, as well as the role of T-bet in acute, chronic infection, inflammation, autoimmune diseases and tumors.
Topics & Concepts
Interleukin 21Cytotoxic T cellInnate lymphoid cellBiologymTORC1Cell biologyInterleukin 12EffectorInflammationTranscription factorCytokineInterleukin 15Innate immune systemImmune systemImmunologyPI3K/AKT/mTOR pathwayT cellSignal transductionCancer researchInterleukinGeneIn vitroBiochemistryImmune Cell Function and InteractionIL-33, ST2, and ILC PathwaysT-cell and B-cell Immunology