Catalytic Atroposelective Synthesis of Axially Chiral Heterobiaryl Oxime Ethers via the One-Step Dynamic Kinetic Condensation Reaction
Qianqian Xu, Jifan Jia, Haitong Fan, Zhifeng Ma, Yuqing Wu, Yifeng Zhang, Ping Su, Wei Gao, Yuji Wang, Dan Li
Abstract
The catalytic atroposelective synthesis of axially chiral heterobiaryls was first developed through the direct one-step dynamic kinetic condensation reaction with the simple transformation of the C═O bond to the C═N bond, delivering a series of novel axially chiral heterobiaryl oxime ethers.
Topics & Concepts
ChemistryAxial symmetryCatalysisCondensationOximeKinetic energyCondensation reactionCombinatorial chemistryComputational chemistryOrganic chemistryThermodynamicsEngineeringPhysicsStructural engineeringQuantum mechanicsAxial and Atropisomeric Chirality SynthesisMolecular spectroscopy and chiralityPlant and Fungal Species Descriptions