Metal centers and aromatic moieties in Schiff base complexes: impact on G-quadruplex stabilization and oncogene downregulation
Aurane Froux, Luisa D’Anna, Aurianne Rainot, Camille Neybecker, Angelo Spinello, Riccardo Bonsignore, Raphaël Rouget, Guillaume Harlé, Alessio Terenzi, Antonio Monari, Stéphanie Grandemange, Giampaolo Barone
Abstract
We present the synthesis and characterization of novel square planar transition metal complexes of Schiff base ligands, which act as guanine quadruplex binders and stabilizers.
Topics & Concepts
Schiff baseGuanineChemistryMetalBase metalG-quadruplexBase (topology)Polymer chemistryTransition metalMaterials scienceOrganic chemistryDNACatalysisBiochemistryMathematicsWeldingGeneMetallurgyMathematical analysisNucleotideDNA and Nucleic Acid ChemistryMetal complexes synthesis and propertiesAdvanced biosensing and bioanalysis techniques