Heterostructured Metal–Organic Frameworks/Polydopamine Coating Endows Polyetheretherketone Implants with Multimodal Osteogenicity and Photoswitchable Disinfection
Yi Deng, Jiacheng Shi, Yau Kei Chan, Ding Bai, Rui Shu, Xiuyuan Shi, Yunfei Li, Limei Li, Xiao Yang, Weizhong Yang
Abstract
Abstract Clinically, bacteria‐induced contagion and insufficient osseointegrative property inevitably elicit the failure of orthopedic implants. Herein, a heterostructured coating consisting of simvastatin (SIM)‐laden metal–organic frameworks and polydopamine nanolayers is created on a porous bioinert polyetheretherketone implant. The heterostructured coating significantly promotes cytocompatibility and osteogenic differentiation through multimodal osteogenicity mechanisms of zinc ion (Zn 2+ ) therapy, SIM drug therapy, and surface micro‐/nano‐topological stimulation. Under the illumination of near‐infrared (NIR) light, singlet oxygen ( 1 O 2 ) and local hyperthermia are produced; besides, NIR light dramatically accelerates the release of Zn 2+ ions from heterostructured coatings. Gram‐positive and ‐negative bacteria are effectively eradicated by the synergy of photothermal/photodynamic effects and photo‐induced accelerated delivery of Zn 2+ ions. The superior osteogenicity and osseointegration, as well as photoswitchable disinfection controlled by NIR light are corroborated via in vivo results. This work highlights the great potential of photoresponsive heterostructured orthopedic implants in treatment of the noninvasive bone reconstruction of bacteria‐associated infectious tissues through multimodal phototherapy and photoswitchable ion‐therapy.