Ophthalmic Nanoemulsions: From Composition to Technological Processes and Quality Control
Agnieszka Gawin-Mikołajewicz, Karol P. Nartowski, Aleksandra J. Dyba, Anna M. Gołkowska, Katarzyna Malec, Bożena Karolewicz
Abstract
properties, pharmaceutical performance, and biological activity of the obtained product. The composition of the formulation has a major influence on the properties of the final product obtained with low-energy emulsification methods. Increasing interest in high-energy emulsification methods is a consequence of their scalability important from the industrial perspective. Considering the high-energy emulsification methods, both the composition and conditions of the process (e.g., device power level, pressure, temperature, homogenization time, or number of cycles) are important for the properties and stability of nanoemulsions. It is advisible to determine the effect of each parameter on the quality of the product to establish the optimal process parameters' range which, in turn, results in a more reproducible and efficient production.