Chiral Carboxylic Acid Assisted Enantioselective C–H Activation with Achiral Cp<sup>x</sup>M<sup>III</sup> (M = Co, Rh, Ir) Catalysts
Tatsuhiko Yoshino, Shigeki Matsunaga
Abstract
Enantioselective C–H functionalization is a powerful tool for synthesizing chiral molecules. In the past few years, the combination of high-valent group 9 metals with achiral Cpx ligands and chiral carboxylic acids (CCA) has emerged as a promising catalytic system to enable selective cleavage and functionalization of enantiotopic C–H bonds. This Perspective summarizes the background, catalyst design, and applied reactions in detail, followed by a discussion of future directions.
Topics & Concepts
Enantioselective synthesisCatalysisChemistrySurface modificationChirality (physics)StereochemistryCarboxylic acidMoleculeCombinatorial chemistryMedicinal chemistryOrganic chemistryChiral symmetryPhysicsNambu–Jona-Lasinio modelQuarkPhysical chemistryQuantum mechanicsCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and CatalysisCyclopropane Reaction Mechanisms