PHLPP1 promotes neutral lipid accumulation through AMPK/ChREBP-dependent lipid uptake and fatty acid synthesis pathways
Keerthana Balamurugan, Raghavender Medishetti, Kotha Jyothi, Parameshwar Behera, Kanika Chandra, Vijay Aditya Mavuduru, Manjunath B. Joshi, Ramesh Samineni, Madhumohan R. Katika, Writoban Basu Ball, Manjunatha Thondamal, Anil K. Challa, Kiranam Chatti, Kishore V. L. Parsa
Abstract
PHLPP1/2 ortholog, abolished lipid accumulation in high cholesterol-fed worms. We conclude that PHLPP1 exerts a significant effect on lipid buildup.
Topics & Concepts
Lipid metabolismLipid dropletChemistryTriglycerideInternal medicineFatty acidEndocrinologyGene knockdownCholesterolBiochemistryCell biologyBiologyGeneMedicineCholesterol and Lipid MetabolismBirth, Development, and HealthLipid metabolism and disorders