The 3′-flap endonuclease XPF-ERCC1 promotes alternative end joining and chromosomal translocation during B cell class switching
Wanyu Bai, Guangchao Zhu, Jiejie Xu, Pingyue Chen, Fei‐Long Meng, Hongman Xue, Chun Chen, Junchao Dong
Abstract
cells. Our study reveals an important role of the flap endonuclease XPF-ERCC1 in A-EJ and oncogenic translocation in mouse B cells.
Topics & Concepts
ERCC1BiologyChromosomal translocationEndonucleaseMolecular biologyNucleotide excision repairDNA repairNucleaseDNACell biologyGeneticsGeneDNA Repair MechanismsCRISPR and Genetic EngineeringPARP inhibition in cancer therapy