The molecular basis for the pH-dependent calcium affinity of the pattern recognition receptor langerin
Jan-Oliver Kapp-Joswig, Jennifer Anders, Hengxi Zhang, Christoph Rademacher, Bettina G. Keller
Abstract
rebinding. These results show how pH regulation of a buried orthosteric binding site from a solvent-exposed allosteric pH sensor can be realized by information transfer through a specific chain of conformational arrangements.
Topics & Concepts
ProtonationChemistryAllosteric regulationAspartic acidBiophysicsHistidineBinding siteStereochemistryHydrogen bondBiochemistryReceptorMoleculeAmino acidBiologyOrganic chemistryIonLipid Membrane Structure and BehaviorEscherichia coli research studiesComplement system in diseases