HDAC1/MAO-B dual inhibitors against Alzheimer’s disease: Design, synthesis and biological evaluation of N-propargylamine-hydroxamic acid/o-aminobenzamide hybrids
Chuansheng Yao, Xiaoying Jiang, Rui Zhao, Zhichao Zhong, Jiamin Ge, Junlong Zhu, Xiang‐Yang Ye, Yuanyuan Xie, Zhen Liu, Tian Xie, Renren Bai
Topics & Concepts
Hydroxamic acidChemistryIC50PharmacologyInhibitory postsynaptic potentialAntioxidantIntracellularBiochemistryStereochemistryIn vitroNeuroscienceMedicinePsychologyCholinesterase and Neurodegenerative DiseasesHistone Deacetylase Inhibitors ResearchAlzheimer's disease research and treatments