Effect of the gut microbiota and their metabolites on postoperative intestinal motility and its underlying mechanisms
Tianrong Ma, XiaoLei Xue, Hui Tian, XinXiu Zhou, Jun-Ke Wang, Zhiwen Zhao, Mingfei Wang, JiYuan Song, Renxiang Feng, Leping Li, Changqing Jing, Feng Tian
Abstract
Gut microbiota is closely related to human health and disease because, together with their metabolites, gut microbiota maintain normal intestinal peristalsis. The use of antibiotics or opioid anesthetics, or both, during surgical procedures can lead to dysbiosis and affect intestinal motility; however, the underlying mechanisms are not fully known. This review aims to discuss the effect of gut microbiota and their metabolites on postoperative intestinal motility, focusing on regulating the enteric nervous system, 5-hydroxytryptamine neurotransmitter, and aryl hydrocarbon receptor.
Topics & Concepts
MotilityGut floraIntestinal motilityDysbiosisGut–brain axisEnteric nervous systemGastrointestinal tractBiologyAntibioticsBioinformaticsMedicineMicrobiologyImmunologyNeuroscienceBiochemistryCell biologyGastrointestinal motility and disordersDiet and metabolism studiesGut microbiota and health