Comprehensive investigation of multiple targets in the development of newer drugs for the Alzheimer's disease
Patil Ashwini, Subhash L. Bodhankar, Muthal Amol, Dileep Kumar, Pawar Atmaram, Ravindra Kulkarni
Abstract
-amyloid was much explored with little success and thus created a feel and palpable growing emphasis on discovering new putative and novel targets for AD. This has inspired medicinal chemists to explore new targets, including microglia, triggering receptors expressed on myeloid cells 2 (Trem-2), and notum carboxylesterase, to discover new lead compounds. This review explores the functions, pathophysiological roles, and importance of all AD-related targets that address therapeutic and preventive approaches for the treatment and protection of Alzheimer's disease.
Topics & Concepts
DiseaseAlzheimer's diseaseNeuroscienceDrug developmentMedicinePsychologyComputer sciencePharmacologyDrugPathologyComputational Drug Discovery MethodsAlzheimer's disease research and treatmentsNuclear Receptors and Signaling