Synthesis and Pharmacological Evaluation of Novel Non-nucleotide Purine Derivatives as P2X7 Antagonists for the Treatment of Neuroinflammation
Francesco Calzaferri, Paloma Narros‐Fernández, Ricardo de Pascual, Antonio M. G. de Diego, Annette Nicke, Javier Egea, Antonio G. Garcı́a, Cristóbal de los Rı́os
Abstract
can be considered as a first non-nucleotide purine hit for future drug optimizations.
Topics & Concepts
ChemistryPurinergic receptorPharmacologyPurineBlood–brain barrierHEK 293 cellsBiochemistryReceptorEnzymeBiologyCentral nervous systemNeuroscienceAdenosine and Purinergic SignalingBipolar Disorder and TreatmentAdolescent and Pediatric Healthcare