Dual-responsive and NIR-driven free radical nanoamplifier with glutathione depletion for enhanced tumor-specific photothermal/thermodynamic/chemodynamic synergistic Therapy
Fanghui Chen, Xichen Zhang, Zining Wang, Chensen Xu, Jinzhong Hu, Ling Liu, Jiancheng Zhou, Bai‐Wang Sun
Abstract
-mediated Fenton-like reaction, but also trigger the decomposition of AIPH to produce biotoxic alkyl radicals (˙R) for TDT. The consumption of GSH and accumulation of oxygen-independent free radicals (˙OH/˙R) synergistically amplified intracellular oxidative stress, resulting in substantial apoptotic cell death and significant tumor growth inhibition. Collectively, this study provides a promising paradigm for customizing stimuli-responsive free radical-based nanoplatforms to achieve accurate and efficacious cancer treatment.
Topics & Concepts
ChemistryRadicalGlutathionePhotothermal therapyBiophysicsHyaluronic acidCancer cellTumor microenvironmentReactive oxygen speciesHydroxyl radicalBiochemistryCancer researchCancerNanotechnologyEnzymeBiologyMedicineMaterials scienceInternal medicineTumor cellsGeneticsNanoplatforms for cancer theranosticsAdvanced Nanomaterials in CatalysisNanoparticle-Based Drug Delivery