Medioresinol as a novel PGC-1α activator prevents pyroptosis of endothelial cells in ischemic stroke through PPARα-GOT1 axis
Yunjie Wang, Xin‐Yuan Guan, Chenglong Gao, Wenchen Ruan, Shunyi Zhao, Guoyin Kai, Fei Li, Tao Pang
Topics & Concepts
PyroptosisMedicineStroke (engine)Activator (genetics)IschemiaIschemic strokeNeuroscienceBrain ischemiaBlood–brain barrierInternal medicineInflammasomeInflammationBiologyCentral nervous systemReceptorEngineeringMechanical engineeringInflammasome and immune disordersBarrier Structure and Function StudiesNeuroinflammation and Neurodegeneration Mechanisms