Getting a lead on Pb<sup>2+</sup>-amide chelators for <sup>203/212</sup>Pb radiopharmaceuticals
Aidan Ingham, Thomas I. Kostelnik, Brooke L. McNeil, Brian O. Patrick, Neha Choudhary, Marı́a de Guadalupe Jaraquemada-Peláez, Chris Orvig
Abstract
Three chelators were developed for potential use in 203/212 Pb-based radiopharmaceuticals. Studies probing the coordination chemistry of the metal complexes and radiolabeling capabilities revealed a compound for future study.
Topics & Concepts
ChemistryChelationLigand (biochemistry)AmideTitrationMetalDenticityPotentiometric titrationMetal ions in aqueous solutionIonCrystallographyIsomerizationNuclear magnetic resonance spectroscopyNuclear chemistryPhysical chemistryCrystal structureInorganic chemistryStereochemistryOrganic chemistryCatalysisReceptorBiochemistryRadiopharmaceutical Chemistry and ApplicationsCoordination Chemistry and OrganometallicsRadioactive element chemistry and processing