Wound Healing Driver Gene and Therapeutic Development: Political and Scientific Hurdles
Xin Tang, Michelle Hao, Cheng Chang, Ayesha Bhatia, Kathrine O'Brien, Mei Chen, David G. Armstrong, Wei Li
Abstract
Significance: Since the last Food and Drug Administration (FDA) approval of a wound healing therapeutic in 1997, no new therapeutic candidate (excluding physical therapies, devices, dressings, and antimicrobial agents) has advanced to clinical applications. During this period, the FDA drug approvals for tumors, which have been referred to as “wounds that do not heal,” have reached a total of 284 (by end of 2018). Both political and scientific factors may explain this large discrepancy in drug approvals for the two seemingly related and equally complex pathophysiological conditions.
Topics & Concepts
PoliticsWound healingMedicinePolitical scienceSurgeryLawBiomedical Ethics and RegulationWound Healing and TreatmentsCancer Research and Treatments