Hypoxia Active Platinum(IV) Prodrugs of Orotic Acid Selective to Liver Cancer Cells
Moumita Maji, Indira Bhattacharya, Sourav Acharya, Manas Pratim Chakraborty, Arnab Gupta, Arindam Mukherjee
Abstract
Platinum(IV) complexes of orotic acid selectively target liver cancer cells displaying enhanced activity and higher uptake in Hep G2. The comparatively higher expression of Organic Anion Transporter 2 (OAT2) in Hep G2 and decrease in toxicity in the presence of OAT2 inhibitor suggest its involvement in the uptake of the complexes. They are resistant to sequestration by the copper transporter ATP7B, unlike cisplatin and oxaliplatin.
Topics & Concepts
ChemistryProdrugOxaliplatinOrotic acidCisplatinPlatinumToxicityTransporterLiver cancerHypoxia (environmental)BiochemistryPharmacologyCancerChemotherapyOxygenInternal medicineGeneColorectal cancerOrganic chemistryCatalysisMedicineMetal complexes synthesis and propertiesMetal-Catalyzed Oxygenation MechanismsLanthanide and Transition Metal Complexes