Poly(2-oxazoline)-based core cross-linked star polymers: synthesis and drug delivery applications
Nedah Alkattan, Noura Alasmael, Viko Ladelta, Niveen M. Khashab, Nikos Hadjichristidis
Abstract
cytotoxicity study using HeLa cells revealed that the neat CCS POxs are compatible with the cells. In contrast, the DOX-loaded CCS POxs exhibited a cytotoxic effect in a concentration-dependent manner in HeLa cells, which strongly supports that the CSS POxs are potential candidates for drug delivery applications.
Topics & Concepts
CopolymerAmphiphileHeLaDrug deliveryClick chemistryPolymerDynamic light scatteringChemistryPolymer chemistrySize-exclusion chromatographyPolymerizationCationic polymerizationMaterials scienceNanoparticleCombinatorial chemistryOrganic chemistryNanotechnologyIn vitroBiochemistryEnzymeSynthesis and properties of polymersAdvanced Polymer Synthesis and CharacterizationDendrimers and Hyperbranched Polymers