An Optimized Screening Approach for the Oxazolidinone Resistance Gene <i>optrA</i> Yielded a Higher Fecal Carriage Rate among Healthy Individuals in Hangzhou, China
Weiyi Shen, Yonglu Huang, Jiachang Cai
Abstract
This study represented an optimized screening approach for the optrA gene, which is an important mechanism of antimicrobial resistance to linezolid as a last resort for the treatment of infections caused by multiresistant Gram-positive bacteria. We revealed a high fecal carriage rate of the optrA gene among adults by this method and reported the first identification of optrA in Lactococcus formosensis as well as the identification of this gene in Vagococcus lutrae and of the poxtA gene in Ligilactobacillus salivarius of human origin, suggesting the wide spread of the optrA gene in the Gram-positive bacterial community.
Topics & Concepts
BiologyFecesCarriageEnterococcusMicrobiologyPopulationLinezolidBacteriaVeterinary medicineGeneticsMedicineVancomycinAntibioticsStaphylococcus aureusEnvironmental healthPathologyAntibiotic Resistance in BacteriaAntimicrobial Resistance in StaphylococcusMycobacterium research and diagnosis