Acetate regulates GAPDH acetylation and T helper 1 cell differentiation
Xizhong Jing, Junfang Lyu, Jianhua Xiong
Abstract
The metabolite acetyl-CoA has emerged as a major signal transducer that can affect cell fate and function by influencing acetylation of key proteins. The mechanism by which acetyl-CoA regulates CD4 + T-cell fate determination remains poorly understood. Herein, it is reported that acetate modulates GAPDH acetylation and CD4 + T helper 1 cell differentiation by altering acetyl-CoA levels.
Topics & Concepts
AcetylationBiologyGlyceraldehyde 3-phosphate dehydrogenaseCell fate determinationCell biologyMetaboliteFunction (biology)Cellular differentiationCellBiochemistryTranscription factorEnzymeDehydrogenaseGeneRNA modifications and cancerVirus-based gene therapy researchUbiquitin and proteasome pathways