Antiproliferative Activity of Ursolic Acid in MDA-MB-231 Human Breast Cancer Cells through Nrf2 Pathway Regulation
Xi Zhang, Tong Li, Er Sheng Gong, Rui Hai Liu
Abstract
-EGFR had no effect on the expressions of Keap1. These results suggested that the proliferative inhibitory effect of UA might be partially through downregulating Nrf2 via the Keap1/Nrf2 pathway and EGFR/Nrf2 pathway in MDA-MB-231 cells.
Topics & Concepts
Ursolic acidKEAP1ChemistryDownregulation and upregulationCell growthCytotoxicityCancer cellCellCancer researchCancerBiochemistryBiologyIn vitroInternal medicineMedicineGeneTranscription factorChromatographyGenomics, phytochemicals, and oxidative stressNatural product bioactivities and synthesisAntioxidant Activity and Oxidative Stress