Amino Acids Enhance Polyubiquitination of Rheb and Its Binding to mTORC1 by Blocking Lysosomal ATXN3 Deubiquitinase Activity
Yao Yao, Sungki Hong, Takayuki Ikeda, Hiroyuki Mori, Ormond A. MacDougald, Shigeyuki Nada, Masato Okada, Ken Inoki
Topics & Concepts
RHEBmTORC1Deubiquitinating enzymeBiologyCell biologyAmino acidLysosomeUbiquitinBiochemistrySignal transductionPI3K/AKT/mTOR pathwayEnzymeGeneUbiquitin and proteasome pathwaysCellular transport and secretionPI3K/AKT/mTOR signaling in cancer