Exosomal LINC00174 derived from vascular endothelial cells attenuates myocardial I/R injury via p53-mediated autophagy and apoptosis
Qiang Su, Xiangwei Lv, Yuli Xu, Ruping Cai, Rixin Dai, Xiheng Yang, Weikun Zhao, Binghui Kong
Abstract
study. In summary, exosomal LINC00174 generated from vascular endothelial cells repressed p53-mediated autophagy and apoptosis to mitigate I/R-induced myocardial damage, suggesting that targeting LINC00174 may be a novel strategy to treat I/R-induced myocardial infarction.
Topics & Concepts
AutophagyMicrovesiclesApoptosisCell biologyExosomeMyocardinCancer researchReperfusion injuryChemistrymicroRNABiologyTranscription factorIschemiaMedicineInternal medicineSerum response factorBiochemistryGeneCancer-related molecular mechanisms researchExtracellular vesicles in diseaseCircular RNAs in diseases