Trifluoromethylation of Carbonyl and Unactivated Olefin Derivatives by C(<i>sp</i><sup><i>3</i></sup>)−C Bond Cleavage
Fei Cong, Riccardo S. Mega, Jinhong Chen, Craig S. Day, Rubén Martı́n
Abstract
Abstract Herein, we report a Cu‐mediated trifluoromethylation of carbonyl‐type compounds and unactivated olefins enabled by visible‐light irradiation via σ C( sp 3 )−C bond‐functionalization. The reaction is distinguished by its modularity, mild conditions and wide scope—even in the context of late‐stage functionalization—thus offering a complementary approach en route to valuable C( sp 3 )−CF 3 architectures from easily accessible precursors.
Topics & Concepts
TrifluoromethylationSurface modificationOlefin fiberSubstituentChemistryCleavage (geology)Context (archaeology)Bond cleavageCombinatorial chemistryOrganic chemistryPhotochemistryMedicinal chemistryStereochemistryCatalysisMaterials scienceTrifluoromethylPhysical chemistryBiologyPaleontologyComposite materialFracture (geology)AlkylFluorine in Organic ChemistryCatalytic C–H Functionalization MethodsInorganic Fluorides and Related Compounds