Intracellular Accumulation of Staphylopine Can Sensitize Staphylococcus aureus to Host-Imposed Zinc Starvation by Chelation-Independent Toxicity
Kyle P. Grim, Jana N. Radin, Paola K. Párraga Solórzano, Jacqueline R. Morey, Katie A. Frye, Katherine Ganio, Stephanie L. Neville, Christopher A. McDevitt, Thomas E. Kehl‐Fie
Abstract
and many other bacterial pathogens rely on metal-binding small molecules to obtain the essential metal zinc during infection. In this study, we reveal that export of these small molecules is critical for overcoming host-imposed metal starvation during infection and prevents toxicity due to accumulation of the metal-binding molecule within the cell. Surprisingly, we found that intracellular toxicity of the molecule is not due to chelation of cellular metals.
Topics & Concepts
IntracellularStaphylococcus aureusChelationBiologyMetal toxicityToxicityZincMicrobiologyMetalBacteriaBiochemistryChemistryInorganic chemistryOrganic chemistryGeneticsTrace Elements in HealthAntimicrobial Resistance in StaphylococcusClostridium difficile and Clostridium perfringens research