An evolutionary framework for treating pediatric sarcomas
Damon R. Reed, Jonathan Metts, Mariyah Pressley, Brooke L. Fridley, Masanori Hayashi, Michael S. Isakoff, David M. Loeb, Rikesh Makanji, Ryan D. Roberts, Matteo Trucco, Lars M. Wagner, Mark G. Alexandrow, Robert A. Gatenby, Joel S. Brown
Abstract
Lessons from extinction can be used in trials designed to pursue a cure for cancer. When cancer cannot be cured, similar strategies may be unwise, and strategies that leverage the adaptations of cancer to therapy should be considered.
Topics & Concepts
MedicineLeverage (statistics)CancerPediatric cancerIntensive care medicineSarcomaCancer therapyInternal medicinePathologyArtificial intelligenceComputer scienceCancer Genomics and DiagnosticsSarcoma Diagnosis and TreatmentRenal and related cancers