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The rise in expression and activity of 11β-HSD1 in human mesenchymal progenitor cells induces adipogenesis through increased local cortisol synthesis

Martina Blaschke, Regine Koepp, Frank Streit, Johannes Beismann, Georg Manthey, Mark‐Tilmann Seitz, Angelique Kragl, Heide Siggelkow

2021The Journal of Steroid Biochemistry and Molecular Biology15 citationsDOI

Topics & Concepts

AdipogenesisCortisoneMesenchymal stem cellGlucocorticoidEndocrinology11β-hydroxysteroid dehydrogenase type 1Internal medicineGlucocorticoid receptorProgenitor cellCell cultureCellular differentiationChemistryCellBiologyEnzymeCell biologyStem cellDehydrogenaseMedicineBiochemistryGeneGeneticsHormonal Regulation and HypertensionAdrenal Hormones and DisordersAdrenal and Paraganglionic Tumors
The rise in expression and activity of 11β-HSD1 in human mesenchymal progenitor cells induces adipogenesis through increased local cortisol synthesis | Litcius