Isocorrole-Loaded Polymer Nanoparticles for Photothermal Therapy under 980 nm Light Excitation
Maximilian R. J. Marek, Trong-Nhan Pham, Jianxin Wang, Qiuqi Cai, Glenn P. A. Yap, Emily S. Day, Joel Rosenthal
Abstract
-glycolic acid) (PLGA) nanoparticles loaded with these designer isocorroles exhibit low toxicity toward triple-negative breast cancer (TNBC) cells in the dark but enable efficient heat production and photothermal cell ablation upon excitation with 980 nm light. These materials represent an exciting new platform for 980 nm activated PTT and demonstrate the potential for designer isocorroles to serve as effective PTAs.
Topics & Concepts
Photothermal therapyNanomaterialsNanoparticleMaterials sciencePLGANanotechnologyOptoelectronicsPhotochemistryChemistryNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesLuminescence and Fluorescent Materials