Phosphodiesterase (PDE) 5 inhibitors sildenafil, tadalafil and vardenafil impact cAMP-specific PDE8 isoforms-linked second messengers and steroid production in a mouse Leydig tumor cell line
Silvia Limoncella, Clara Lazzaretti, Elia Paradiso, Sara D’Alessandro, Federica Barbagallo, Salvatore Pacifico, Renzo Guerrini, Simonetta Tagliavini, Tommaso Trenti, Daniele Santi, Manuela Simoni, Marcó Sola, Giulia Di Rocco, Livio Casarini
Topics & Concepts
VardenafilTadalafilEndocrinologyIntracellularcGMP-specific phosphodiesterase type 5Internal medicinePhosphodiesteraseCyclic nucleotideCyclic adenosine monophosphateSecond messenger systemPDE10ALeydig cellSildenafilCyclic guanosine monophosphateCYP17A1BiologyTestosterone (patch)Cell biologyMedicineBiochemistryReceptorNucleotideEnzymeHormoneLuteinizing hormoneNitric oxideGeneSexual function and dysfunction studiesPhosphodiesterase function and regulationHormonal and reproductive studies